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• Puff, puff, puff, nicotine rises gradually 

Nicotine builds up gradually in smokers' brains rather than spiking after each puff, according to a study that might help point to new ways to help people quit smoking.

Dr. Jed E. Rose of Duke University reports in Monday's online edition of Proceedings of the National Academy of Sciences that nicotine buildup in the brain was gradual over several minutes.

Scientists have theorized that there is a spike of nicotine in the brain about seven seconds after each puff, but almost no measurements had been taken until now, Rose said in a telephone interview.

"We were surprised to find that the rate of uptake was much different from what one commonly hears," said Rose, who directs the Duke Center for Nicotine and Smoking Cessation Research, a part of the university's School of Medicine.

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