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A Transdermal Nicotine Patch Is Not Effective for Postoperative Pain Management in Smokers: A Pilot Dose-Ranging Study 

Anesth Analg 2009; 109:1987-1991 Volume 109, Issue 6 (December 2009)
Jump to full article: Anesthesia & Analgesia, 2009-11-22
Author: Luke C. Olson, BA, Daewha Hong, MS, Jessamyn S. Conell-Price, BA, Sean Cheng, MS, and Pamela Flood, MD

Intro:

BACKGROUND: Nicotine has an antinociceptive effect in animal models. The analgesic effect in humans has been examined, but studies have had mixed results. . . .

CONCLUSIONS: Transdermal nicotine, 5-15 mg, failed to relieve postoperative pain or reduce opioid use in smokers.

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