Jump to full article: State Press (Arizona State University), 2009-09-03
Author: Jessica Testa
Intro: An ASU professor is challenging widely held conceptions about smoking, including challenging the view that nicotine is addictive.
Peter Killeen, emeritus professor of psychology in the College of Liberal Arts and Sciences, presented his research findings for the National Institute on Drug Abuse on the Tempe campus Wednesday afternoon.
The talk was called “Reefer Madness: There ain’t no such Thing as Addiction to Nicotine.”
NIDA initially invited Killeen to look into ways to improve scientific research on drug abuse, specifically nicotine addiction.
“I came up with a shocking discovery,” Killeen said. “There’s no such thing as nicotine addiction.”
“It’s time to get our heads straight,” Killeen said. “What causes the tremendously addicting power of cigarettes is the drug cocktail of nicotine,” he said, not nicotine itself.
Before he got into his findings, Killeen said he wanted to make clear that tobacco kills. . . .
“Studies have shown that none of the nicotine replacement therapies — chewing gum, inhalers, patches — none of those are addictive,” he said. “Nicotine is not addictive. So what’s going on?”
The cause of addiction is the release of monoamine oxidase inhibitors, or MAOIs, along with nicotine, Killeen said.
While nicotine affects the release of dopamine, or the “reward hormone” that affects emotions and movement, MAOIs help regulate dopamine levels, Killeen said.
“When you put together something that directly releases dopamine and another thing that helps the brain clean up excess dopamine, you’ve got a one-two punch,” he said. “It is my hypothesis that it’s a combination of nicotine with some of these other chemicals that causes the powerful addiction.”
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