Jump to full article: Cancer Research UK (uk), 2009-08-20
Author: Cancer Research UK Press Release
Intro: CANCER RESEARCH UK funded scientists have confirmed that inherited changes in certain regions of the genome can increase a smokers' risk of developing lung cancer lung cancer, and determine the type of lung cancer that develops. Their results were published in this week's edition of the journal Cancer Research*.
The researchers at The Institute of Cancer Research scanned the genomes of 1,900 lung cancer patients and compared them to 1,400 healthy individuals to identify specific changes in the DNA that were linked with an increased risk of lung cancer.
They then scanned the genes of a further 2,000 lung cancer patients for these changes and compared these to a similar number of healthy people.
This identified changes in three regions of the genome which were more common in lung cancer patients than healthy individuals. These regions sat on chromosomes 5, 6, and 15, implicating these regions in lung cancer.
Their work shows more complexity than originally thought for the chromosome 15 association.
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