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· International
· Cancer
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Clinical Gastroenterology and Hepatology Volume 7, Issue 6, June 2009, Pages 682-688.e5
Jump to full article: Science Direct, 2009-06-01
Intro: Smoking has been implicated in many malignant diseases, but its association with colorectal cancer (CRC) is controversial. We quantitatively evaluated the relation between smoking and incidence of CRC in a meta-analysis of cohort studies.
Methods
Full publications of prospective cohort studies were identified in MEDLINE and EMBASE from 1950 to 2008. Subjects were classified as current smokers, former smokers, or never smokers. The quantity of smoking was assessed by number of cigarettes per day, years of smoking, and pack-years. The reported relative risks of CRC were pooled by random-effects model. Sensitivity analysis was conducted, and publication bias was evaluated.
Results
A total of 1,463,796 subjects were recruited in 28 prospective cohorts from America, Europe, and Asia . . .
Conclusions
Smoking was associated with a significantly increased risk of CRC. The associated risk was higher for men and for rectal cancers. The association of tobacco consumption and CRC risk appeared to be dose-related.
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