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Longitudinal Tracking of Left Ventricular Mass Over the Adult Life Course. Clinical Correlates of Short- and Long-Term Change in the Framingham Offspring Study  

Conclusions--Our longitudinal observations on a large community-based sample identified higher blood pressure, excess adiposity, smoking, and diabetes mellitus as fundamental determinants of LV mass tracking over the adult life course. These observations are consistent with the notion that maintenance of optimal levels of these risk factors in midlife will reduce the burden of LV hypertrophy, and possibly heart failure, in older age.

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