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· Lung Cancer
· Nicotine
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Inhibition of Nonneuronal {alpha}7-Nicotinic Receptor for Lung Cancer Treatment  

Vol 179. pp. 1141-1150, (2009) Volume 179, Issue 12; June 15, 2009
Jump to full article: American Journal of Respiratory and Critical Care Medicine, 2009-06-09

Intro:

Rationale: Studies strongly suggest that the nicotinic acetylcholine receptors for nicotine (nAChRs) play a significant role in lung cancer predisposition and natural history. The nAChR {alpha}7 subunit has been found to be pivotal in the control of nicotine-induced lung cancer development and in growth signal transduction induced by nicotine binding to nAChRs. . . .

Conclusions: We report the prolonged survival of {alpha}-CbT–treated animals in our mouse model of NSCLC, which is most likely the result of multiple mechanisms, including various antiproliferative and antiangiogenic effects.

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