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Chantix side effects no worse with depression history 

Group Health studies over 1,000 smokers in COMPASS trial
Jump to full article: EurekAlert, 2009-03-02

Intro:

People with a likely history of depression who take varenicline (Chantix�) do not report more severe mood symptoms, medication side effects, or less success quitting smoking compared to people with no history of depression taking this drug.

The findings by Group Health, Free & Clear, and SRI International researchers are reported in a Journal of General Internal Medicine article published online (http://www.springerlink.com/content/77207452k3822r3v/). The National Cancer Institute (NCI)-funded, randomized COMPASS trial tracked more than 1,100 Group Health patients receiving behavioral treatment and varenicline to quit smoking. It's the first "real-world" examination of varenicline use since the original Food and Drug Administration (FDA) studies that the manufacturer funded.

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