M. D. Anderson-led team's whole-organ genomic survey depicts journey from normal to malignant cell
Jump to full article: EurekAlert, 2008-05-05
Author: geographically relating an organ
Intro: Whole-organ maps that superimpose genetic information over the terrain of cancerous bladders chart the molecular journey from normal cell to invasive cancer, an international research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports online at the journal Laboratory Investigation, a member of the Nature Publishing Group.
By geographically relating an organ's varied tissues - normal, precancerous and malignant - to their underlying genetic variation or regulation, the team also identified a crucial new category of genes that launches the process of cancer development. . . .
A gene known as P2RY5 located inside a portion of the RB1 gene was affected by a number of single-nucleotide changes. A case-control study of one of the gene's variant forms was conducted using blood DNA from 790 bladder cancer patients and 712 controls matched for age and gender. The specific variation was present in 2.78 percent of patients and every patient with the variation who also smoked developed bladder cancer.
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