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· Iceland
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Findings will be applied to diagnostic efforts and will be integrated into the deCODEme(TM) service
Jump to full article: PR Newswire, 2008-04-02
Author: Source: deCODE
Intro: Today scientists from deCODE genetics and their colleagues from several universities report in the journal Nature a clear link between a single-letter variant in the sequence of the human genome (SNP) and susceptibility to nicotine dependence. Moreover, in part because of this impact on smoking behavior, each copy of the risk variant of this SNP confers an approximately 30% increase in risk of lung cancer and a 20% increase in risk of peripheral arterial disease (PAD) . . .
The SNP, rs1051730, is located on chromosome 15q24 in a nicotine acetylcholine receptor called CHRNA3. The paper, 'A variant associated with nicotine dependence, lung cancer and peripheral arterial disease,' is published today in the online edition of Nature, at www.nature.com.
"These findings provide an example of the power of human genetics for shedding light on the most complex health challenges. . . .
The deCODE team began this study with a smoking history questionnaire distributed to some 50,000 Icelanders
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