A Controlled Trial of Naltrexone Augmentation of Nicotine Replacement Therapy for Smoking Cessation 

Conclusions The 100-mg dose of naltrexone hydrochloride appears the most promising for augmenting the efficacy of the nicotine patch on smoking cessation outcomes but requires further study. The significant weight reduction with low-dose naltrexone therapy suggests that it may be useful as a second-line treatment for weight-concerned smokers.

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