Tobacco.org

Chemoprevention of lung cancer by non-steroidal anti-inflammatory drugs among cigarette smokers.  

Information on the use of aspirin, ibuprofen, and prescription NSAIDs was obtained by personal interviews. Effects of NSAIDs on lung cancer risk were assessed by estimating odds ratios (relative risks) with 95% confidence intervals and performing trend tests. Daily intake of NSAIDs for at least 2 years prior to interview was associated with a 68% reduction in the relative risk of lung cancer (RR, 0.32; 95% CI, 0.23-0.44; p<0.01). The inverse trend of lung cancer risk with increasing NSAID use was highly significant (p<0.01). Results were similar for men (RR, 0.41) and women (RR, 0.22), and for the individual compounds, aspirin (RR, 0.25) and ibuprofen (RR, 0.39). These results combined with the current molecular evidence suggest that regular NSAID intake may prevent tobacco carcinogenesis through COX-2 blockade.

Jump to full article »